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Kids will discover that reading can engage all five senses, and that what they themselves bring to a book is an important contribution. ![]() This picture book is an invitation to honour your own vision and to welcome imperfection. s of people free their creativity and find their own voice with her interactive books, and now she brings that sensibility to children and to the act of reading. books-i-own Novemas a perfectionist and lover of symmetry this was daring, because it required chaos and a bunch of mess.i had soo much fun. We are all part of the books we read, because our individual reactions, ideas, and emotions make the book whole, and these things are changing all the time.Keri Smith has helped million. Keri Smith is a Canadian conceptual artist and author of several bestselling books and apps about creativity including Wreck This Journal (Penguin), This is Not a Book (Penguin), How to be an Explorer of the World -the Portable Life/Art Museum,(Penguin), Mess: A Manual of Accidents and Mistakes (Penguin), The Guerrilla Art Kit (Princeton Archite. What if there were a book that changed every time you read it? Actually, every book does this. ![]() ![]() ![]() Overview of the Cytoscape Automation ecosystem. Both REST and JSON are already in wide use in client/server computing, are accessible from most programming languages, are immediately understood by most bioinformaticians, and are easy to learn given the massive body of relevant training materials, examples, and extant community. Under Cytoscape Automation, workflows can use CyREST to issue commands to Cytoscape and automation-enabled apps via the REST protocol, which encodes data as JSON documents. ![]() 1, Cytoscape Automation is a new Cytoscape feature that addresses these issues by extending the existing CyREST app, which empowers bioinformaticians to create reproducible workflows expressed in robust and well-known programming languages (e.g., Python, R, Javascript) using familiar programming environments (e.g., Jupyter and RStudio). ![]() Finally, as an interactive tool, Cytoscape is not positioned to add value to emerging workflows that integrate one or more external data acquisition and analysis tools (e.g., Galaxy, Taverna, and libraries provided in repositories such as PyPI and Bioconductor ).Īs shown in Fig. Moreover, while Cytoscape apps provide highly performant and relevant network biology functionality, the specialized programming talent and relatively long development times they require can make them uneconomical for delivering complex and evolving workflows. However, interactive use has proven inadequate for precisely reproducing or sharing complex analyses or for scaling to high volume or production analysis. Investigators can interactively explore complex *omics datasets via analysis and visualization functions provided by Cytoscape and a large and vibrant community of app contributors. As a platform for network biologic analysis, Cytoscape has proven to be enormously popular, with over 17,600 downloads worldwide each month, 5000 startups each day, and over 1000 direct citations per year. ![]() ![]() For example, the diesel loco has two engines, while the electric loco has three. Some locos have two engines, and some have three. Each type has its own characteristics, and they differ from one another. You can choose between four types of locomotives: diesel, electric, diesel-electric and gas. You can control your locos on any train network in the world, from the smallest local line to the biggest international network. 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Trainz simulator 3 mod apk is the next-generation simulation game that allows you to become a train driver and control everything through your fingers. Many of us cannot afford plane driving but train driving is one of the cheapest modes of transportation nowadays. The train is the fastest mode of transportation after airplanes. ![]() ![]() (Note: Japanese people don't use middle names.) This is rather like Japanese addresses, which go from broad (one of 47 prefectures) to specific (house number), also the reverse of the English order. The exception is for foreigners, whose names can go in either order. Japanese Name Orderįull names in Japanese are always said with the family name (surname) first, personal name (given name) second. On the other hand, you should never use a suffix with your own name. No suffix at all is a very intimate way to address someone, and is usually not appropriate. So if someone is san to you when you're talking to them face to face, they're san all the time. This is the same way you would always refer to the person, even when they're not around: with the suffix that represents your relationship to them. Instead of saying "you", in Japanese you simply say the person's name with the appropriate name suffix. Often simply used in place of the persons name when addressing them directly, or when it's obvious which teacher you're referring to. Literally "one who has gone before", used with teachers, professors, doctors, and masters of any trade. Also sometimes used with pets and other cute animals. Occasionally used with both males and females of lower rank.Ī diminuative, used with young children and with close female friends. Often with male students, and with male friends (children and young adults). General purpose, gender neutral, equivalent to Mr./Mrs./Ms. They also depend on the speaker and listener's relative ranks. Name suffixes are another example of Japanese honorifics, but unlike "o", they are never optional. When actually using someone's name, you would generally include a name suffix as well. Note that you would never refer to your own name as o-namae, it would be just namae. This is often used after giving one's name to prompt the other person to give theirs. "O-namae wa?" is short for the question: おなまえは なんですか。īut the short form is generally used instead. Asking for NamesĪsking for someone's name is a simple task. In reality, there's some variation, but this much is fine for now. So, in summary, here is a (perhaps overly) typical exchange: Put these three parts together and you should be able to understand the standard translation, a request for the other person to treat them well.Īfter the first person finishes, the other person will then give their name and "yoroshiku". This expression is often used as part of a request. "Shimasu" is a verb meaning "to do", so "o-negai shimasu" means to wish for something. The prefix "o" is an honorific, shows respect towards the listener. It comes from the polite adjective "yoroshii", meaning good. "Yoroshiku" means "well", understandably enough. You'll learn the other Japanese word translated as "please" (kudasai) when we get to command verbs. It carries politeness, but is not a command. ![]() "Douzo" means "please", in the sense of "please sit down". To understand this one better, let's break it down. The closest English equivalent of all of these is "Nice to meet you". An even more informal version would be "yoroshiku" or "yoroshiku, ne". どうぞ よろしく おねがいします。Īll of these mean roughly the same thing, though omitting "o-negai shimasu" makes it less formal. This one is optional for now, but I've included it here for completeness.Īfter giving their name, the speaker ends with one of the following expressions. " to moushimasu" is much more polite as it uses a humble verb, and is typically used when introducing yourself to someone of a higher rank. Introductions definitely count as such a context. The "watashi wa" portion of sentences with "I" as the subject can be stiff sounding and usually omitted if obvious from context. ![]() Read more about the topic marker "wa" and the copula "desu" Pronunciation note: The 'su' in "desu" and "masu" is always devoiced, so they sound like de-s and ma-s respectively. Next, one person gives their name, using one of two patterns. ![]() The closest English equivalent is "How do you do?". The expression is derived from the verb "hajimeru", meaning "to do (something) for the first time". ![]() Pronunciation note: the 'shi' in "hajimemashite" has an unvoiced vowel, so it sounds like ha-ji-me-ma-*sh*-te. When meeting someone for the first time, the standard introduction has two parts. No grammar knowledge is required, but you should at least know the basics of Japanese pronunciation before you start. In this section you'll learn how to introduce yourself, ask for someone's name, and use Japanese name suffixes. But rather than just giving you a list, I'll explain what each means and the differences between variants. As is customary in any foreign language course, we'll do lots of common expressions early on. ![]() ![]() However, McQueen had never brought Mater to any of his races, but he decided to take him along for the World Grand Prix after being given advice from Sally. In Cars 2, it is shown that McQueen's friendship with Mater has remained stronger than ever before where the two had a special handshake to greet each other, which according to Mack, their greetings get longer every year. Despite this, McQueen works with Mater on several adventures and enjoys spending time with him. McQueen can sometimes get frustrated with Mater for several things, such as in Mater’s Tall Tales when he tells him stories about what he did in the past, to which McQueen would not believe, especially when they have himself suddenly participating, before seeing references to Mater's stories that suggest they are true. ![]() Later, McQueen asked Tex Dinoco to give Mater a ride in one of Dinoco's helicopters, fulfilling his promise to Mater, becoming best friends with him. When McQueen forfeited his chance to win the Piston Cup by helping the injured King cross the finish line, he was congratulated by Mater for his good sportsmanship. When Mater and some of the townsfolks from Radiator Springs came to be McQueen's pit crew and support him in the tie-breaker race in California, McQueen was happy to see Mater and gave a heartful laugh when Mater delivered his good-bye to him. However, as McQueen was soon transported away from the town by the press, he was hesitant to leave Mater and the others behind and when he arrived at his race, he could not stop thinking about Mater and the other Radiator Springs citizens he befriended. It was this moment that McQueen and Mater developed a strong bonding friendship.Īfter McQueen decided to stay in Radiator Springs to help the townsfolk, Mater is overjoyed to see that McQueen has stayed. McQueen then promised to give Mater a helicopter and upon hearing Mater says he sees McQueen as a best friend, McQueen looks touched. When Mater later took him tractor tipping, McQueen was unimpressed at first, but then enjoyed it after being given a try, although they had to immediately leave when they caught the attention of Frank.Īfter seeing Mater show his ability of driving backwards, McQueen explained to him about the Piston Cup, but when he mentioned that winning it would mean he would no longer have a sponsorship that has no involvement with rusty cars, he tried not to hurt Mater's feelings by saying that he meant other vehicles, but liked Mater. McQueen was afraid at first when seeing Mater, due to him being a rusty vehicle, but later tried to get Mater to take him out of the impound by suggesting a cruise around the town. ![]() McQueen first met Mater while he was put in the impound by Sheriff, having destroyed Radiator Springs' main road. Lightning McQueen and Mater high-five each other Uncle Topolino: " This Mater is a close friend?" Lightning McQueen: " He's my best friend" ―McQueen describing his friendship with Mater. ![]() ![]() Revenue: Total revenue was $14.6 million for the quarter ended June 30, 2021, as compared to $3.6 million for the quarter ended June 30, 2020. We expect cash and cash equivalents to be sufficient to fund operations into the second half of 2023. ![]() Initiation of a clinical trial with 4D-710 in cystic fibrosis lung disease expected in the fourth quarter of 2021įinancial Results for the Second Quarter Ended June 30, 2021Ĭash and Cash Equivalents: Cash and cash equivalents were $243.7 million as of June 30, 2021.Initiation of a clinical trial with 4D-150 in wet AMD expected in the fourth quarter of 2021.Initial clinical activity data from the Phase 1 clinical trial of 4D-110 in choroideremia expected in the fourth quarter of 2021.Initial clinical activity data from the Phase 1/2 clinical trial of 4D-125 in XLRP expected in the fourth quarter of 2021. ![]() Initial clinical data from the Phase 1/2 clinical trial of 4D-310 in Fabry disease expected in the fourth quarter of 2021.We also plan to submit to the FDA safety and efficacy data from the 4D-110 Phase 1 clinical trial along with a new 4D-110 clinical study protocol in the fourth quarter of 2021. We expect to report initial clinical activity data from the Phase 1 clinical trial of 4D-110 in choroideremia and the Phase 1/2 clinical trial of 4D-125 in XLRP in the fourth quarter of 2021. Updated our rare disease ophthalmologic portfolio: reported positive initial safety data from the Phase 1 clinical trial of 4D-110 in choroideremia and the Phase 1/2 clinical trial of 4D-125 in X-linked retinitis pigmentosa (XLRP) and regained global rights to 4D-110.in Organization Development and Clinical Psychology. Greiner has served as head of human resources for 25 years at organizations including California Pacific Medical Center, the Palo Alto Medical Foundation at Sutter Health, The Institute on Aging, and Bank of America. Zimmermann brings over 27 years of leadership experience in life sciences corporate and business development, including from her prior roles at Johnson & Johnson Innovation and Novartis Pharmaceuticals. Appointed Carolyne Zimmermann as Chief Business Officer.The expanded facility will enable commercial-scale manufacturing of our clinical product candidates and expansion of our analytical development capabilities, including laboratories dedicated for developing potency assays. ![]() Initiated the expansion of current Good Manufacturing Practices (cGMP) compliant manufacturing facilities and analytical laboratories at 4DMT headquarters in Emeryville, CA to support manufacturing and analytical testing of current and future product candidates.We remain on track to announce clinical data from each of our three ongoing clinical programs and to initiate clinical development with product candidates in wet AMD and cystic fibrosis by the end of this year.” In addition, we enhanced our leadership team with the additions of Carolyne Zimmermann as Chief Business Officer and Nadine Greiner, Ph.D., as Chief Human Resources Officer. This achievement underscores the promise of our Therapeutic Vector Evolution platform, which empowers us to invent targeted and evolved vectors that package efficiently during our proprietary manufacturing process. Notably, we believe we are the first AAV gene therapy company to successfully complete cGMP manufacturing of primate-evolved targeted vectors, and we achieved this milestone with three different clinical product candidates. “Importantly, we initiated the expansion of our cGMP manufacturing facilities to support commercial-scale production of our clinical product candidates. “Harnessing the power of directed evolution to develop targeted gene therapies is central to 4DMT, and this past quarter we continued to make substantial progress towards our goal,” said David Kirn, M.D., Co-founder and Chief Executive Officer of 4DMT. 12, 2021 (GLOBE NEWSWIRE) - 4D Molecular Therapeutics (Nasdaq: FDMT), a clinical-stage gene therapy company harnessing the power of directed evolution for targeted gene therapies, announced financial results for the second quarter of 2021, and provided operational highlights. ![]() ![]() ![]() Using the same switch for switching both the light and fan (Single switch).Switching the light and using the pull chain for the fan (Single switch).Powered ceiling fan and/or light without any switches (no switches).We’ll go through each type of switching methodology and discuss what each entails in terms of wiring and controlling your ceiling fan/light. Read all the instructions and safety information that comes with your ceiling fan. When working with electricity, always remember to turn off the power, test the wiring with an electrical tester (or voltmeter) to ensure the power is off, secure the panel box so no one can accidentally re-engage power while you are working, and consult a professional to ensure you are doing things correctly and within the specifications of your state and local codes. ![]() Permits may be required for interior electrical work. It’s always important to follow the local codes in your area when wiring a ceiling fan and light. A pair of actual wire strippers will do the job more accurately and about 10x faster. It also ensures you don’t get bogged down trying to use, for example, a razor knifed to strip wires. Having the right tools will help the project go smoothly. For some, that will be any combination from no switches (using the included pull chains for powering the fan and/or light) and having separate switches for the light and fan. The main thing to consider wiring a ceiling fan and light is determining how you want that fan to be controlled. ![]() |
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